Sildenafil Citrate is a medicine discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett. It was originally intended to serve as treatment for various cardiovascular diseases. However it was inducing penile erections in the patients and not helping as much as they would have hoped for Angina. For this reason in 1998 it became available as treatment for erectile dysfunction instead.
It originally became commercially under the name Viagra, launched by Pfizer. But with time other generic brands have surged commercially such as Cenforce by Centurion Laboratories, Aurogra by Aurochem Laboratories, Caverta by Sun Pharmaceutical Industries, Agra by Alliaance Biotech, and many more. All of these are commonly used in men with erectile dysfunction, but what is erectile dysfunction?
Erectile dysfunction (ED) is a condition that consists in the inability of the man to produce an erection, retain an erection or cause an erection firm enough for sexual intercourse. In a normal person an erection is achieved when the brain senses a sexual urge sending nerve signals to the penis. The muscles in the penis receiving these signals begin to relax. This relaxation of the penile muscle causes blood to flow into the soft tissue of the penis and the veins shut off to keep the blood from flowing out. This causes the penis to enlarge and grow firm. So in order to produce an erection the veins and arteries, muscles and nerves have to work together. If one of these processes fail due to disease then an erection might not be able to be achieved efficiently or at all.
Diseases that affect the cardiovascular system, muscles and nerves are the main cause of erectile dysfunction. Since usually these sort of health issues surge in old age it is more common for people over 40 years old to suffer from erectile dysfunction. In fact one in five men over the age of 40 have erectile troubles and about one in ten men are completely unable to have erections. But all hope of intimacy is not lost to every man over 40 thanks to Sildenafil Citrate. This medicine acts by blocking an enzyme called Phosphodiesterase type 5 (PDE5). This enzyme blocks the chemicals that produce blood flow to the penis therefore allowing the penis to be filled efficiently with blood and achieve an erection. The drug should be taken from 30 minutes to 4 hours before intercourse depending on the dosage (the sildenafil 100mg is the most popular). It is not recommendable to take it more than once a day.